permission is required to reuse all or part of the article published by MDPI, including figures and tables. Applied logistic regression. The secondary aim was to assess the reproducibility of DS in the interpretation of PET-CT scans. Furth, C.; Steffen, I.G. Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT. Nat. Desai, S. H., Al-Shbool, G., Desale, S., Veis, J. J. Nucl. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. WebDeauville Criteria Deauville 1: No FDG uptake Deauville 2: FDG uptake < or = mediastinal blood pool Deauville 3: FDG uptake > mediastinal blood pool and < or = normal liver parenchyma Deauville 4: FDG uptake greater than normal liver parenchyma Deauville 5: FDG uptake significantly greater than normal liver parenchyma or new FDG-avid lesions An official website of the United States government. Vol. Oncol. Radiomic features were extracted using PyRadiomics (Version 3.0)25,26, following the instructions of the Image Biomarker Standardisation Initiative (IBSI)27. Med. ISSN 2045-2322 (online). If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. ; Bogue, M.K. ; investigation, S.P. Copyright 2023 American Academy of Family Physicians. Lymphoma is a group of malignant neoplasms of lymphocytes with more than 90 subtypes. National Library of Medicine ; Hudson, M.M. Careers. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Younes A, Santoro A, Shipp M, et al. Lymphoma 50, 12571260. Bull. Imaging in staging of malignant lymphoma: A systematic review. J. Nucl. Yhim HY, Eshet Y, Metser U, Lim CH, Lajkosz K, Isaev K, Cooper M, Prica A, Kukreti V, Bhella S, Lang N, Lee KH, Xu W, Hodgson D, Tsang R, Yoon SE, Kim SJ, Kim WS, Crump M, Kuruvilla J, Kridel R. Blood Adv. Introduced to improve the consistency of PET interpretation3,4, the DS visually relates FDG uptake of a lymphoma manifestation to regions of physiological activity, i.e., the liver and the mediastinal blood pool5. and B.H. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. 58, 282287. Patient-related examination details and distribution of Deauville Scores are listed in Table 2. Data were analyzed using the SPSS software package, version 20.0 (. The results of the present study show that the first-order feature median has a high sensitivity for DS4+ manifestations on two different scanners (scanner A: 0.91, scanner B: 0.85). 3D Slicer as an image computing platform for the Quantitative Imaging Network. You are using a browser version with limited support for CSS. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). sharing sensitive information, make sure youre on a federal Department of Radiology, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany, Laura J. Jensen,Damon Kim,Juliana Rieelmann,Bernd Hamm,Ingo G. Steffen,Thomas Elgeti&Sebastian N. Nagel, Department of Nuclear Medicine, Charit-Universittsmedizin Berlin, Corporate Member of Freie Universitt Berlin, Humboldt-Universitt zu Berlin, and Berlin Institute of Health, Augustenburger Platz 1, 13353, Berlin, Germany, Julian M. M. Rogasch,Christian Furth&Holger Amthauer, Berlin Institute of Health (BIH), Berlin, Germany, You can also search for this author in Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. Epub 2022 Jul 25. The first-order feature median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability. Context: Positron emission tomography (PET) using F-18 fluorodeoxyglucose (FDG) for treatment monitoring in patients with lymphoma is one of the most well-developed clinical applications. Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: The Lugano classification. Interv. Characteristics. 2013;54(11):2531-2533. ; Contact Us Have a question, idea, or some feedback? In particular, international guidelines recommend using the Deauville criteria to assign patients a score of 1 through 5, indicating their response to treatment as Aleman, B.M.P. PET/CT, however, is not always available or may be missing for one or more time points, precluding a reliable prognostic statement based on metabolic activity. A family history of a specific subtype of lymphoma is associated with developing that same subtype.5 There are three main mechanisms through which infection increases lymphoma risk: direct transformation of lymphocytes, immunosuppression, and chronic antigenic stimulation6 (Table 26,7). ; software, S.N.N. 3: 445. The Deauville 5-point scoring system is an internationally accepted and utilized five-point scoring system for the fluorodeoxyglucose (FDG) avidity of a Hodgkin lymphoma or Non-Hodgkin lymphoma tumor mass as seen on FDG positron emission tomography:[1], Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. WILLIAM D. LEWIS, MD, SETH LILLY, PharmD, BCPS, AND KRISTIN L. JONES, PA-C. Related editorial: Breast Implant-Associated Anaplastic Large Cell Lymphoma. Lymphoma spreads to extranodal sites by direct invasion or by hematogenous spread to the spleen, liver, lungs, or bone marrow.14,15 High-grade lymphomas can present as oncologic emergencies because of the structural compression from the enlarging tumor, including superior vena cava syndrome, malignant epidural spinal cord compression, or malignant pericardial effusion.16 Paraneoplastic syndromes are rare with lymphoma, occurring as paraneoplastic cerebellar degeneration in Hodgkin lymphoma and as dermatomyositis and polymyositis in Hodgkin and non-Hodgkin lymphomas.17, The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry.3 Although fine-needle aspiration and core needle biopsy are often part of the initial evaluation of any adenopathy, neither will provide adequate tissue for the diagnosis of lymphoma because of the need to verify Hodgkin lymphoma via the presence of Reed-Sternberg cells.15,18, The Ann Arbor staging system was initially developed in 1971 for Hodgkin lymphoma, and was later adapted for non-Hodgkin lymphoma. SoftwareX 16, 100819. https://doi.org/10.1016/j.softx.2021.100819 (2022). WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. Prognostic value of pretransplant FDG-PET in refractory/relapsed Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review and meta-analysis. Got his first Pet scan result 6 weeks after his last R-Chop, doctor said that his Deauville score is 2 which means that he is considered to be in metabolic remission. Of these, only median remains after applying different feature reduction methods. Conclusions: Our study confirmed that DS is a useful tool to aid in reporting F-18 FDG PET-CT in the management of HL with good positive and negative predictive values. A p-value<0.05 was generally considered to indicate statistical significance. ; formal analysis, S.N.N., L.J.J., D.K., J.R, investigation, S.N.N., J.M.M.R., C.F., H.A. https://doi.org/10.1038/s41598-022-24227-0, DOI: https://doi.org/10.1038/s41598-022-24227-0. J. Nucl. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Required fields are marked *. The study was conducted in accordance with the Declaration of Helsinki. A Feature Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Mol. ; writingreview and editing, F.I., M.G., L.F.; supervision, S.P., D.C., E.N. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. Web- The Deauville score for interpreting FDG-PET in lymphoma - Lugano classification for staging of lymphomas - Unfavorable prognostic factors early HL - IPS Hodgkin lymphoma; Figures - Lymph node regions lymphoma; CALCULATORS. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Prognostic value of pretreatment radiomic features of 18F-FDG PET in patients with hodgkin lymphoma. Isik, E.G. Google Scholar. Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing. The sensitivity, specificity, PPV, NPV and accuracy of interim DS in predicting a therapy response at 24 months were 80.4%, 100.0%, 100.0%, 40.0% and 82.7%, respectively. A score of 4 or 5 is an indicator to consider escalating therapy.25 Patients with Hodgkin lymphoma with a Deauville score of 1 or 2 have been shown to have similar progression and mortality outcomes between radiotherapy and no further treatment.32 Patients who receive a score of 3 or 4 should receive additional chemotherapy and/or radiotherapy, and a score of 5 indicates the need for a biopsy (excisional or core needle) in addition to chemotherapy and radiotherapy.25 A positive biopsy should be considered refractory disease.25, Relapse rates for non-Hodgkin lymphoma are variable and based on the specific subtype. CT-based texture analysis potentially provides prognostic information complementary to interim fdg-pet for patients with hodgkins and aggressive non-hodgkins lymphomas. and JavaScript. qPETA quantitative extension of the Deauville scale to assess response in interim FDG-PET scans in lymphoma. To indicate statistical significance //doi.org/10.1038/s41598-022-24227-0, DOI: https: //doi.org/10.1038/s41598-022-24227-0, DOI https.: https: //doi.org/10.1038/s41598-022-24227-0 and inflammatory etiologies also contributing analyzed using the SPSS software package, 20.0..., E.N for Relapsed or Refractory Hodgkin lymphoma: the Role of Comorbidity and... In Table 2 scanners, indicating cross-scanner applicability MDPI, including figures and tables inflammatory also. Ds in the interpretation of PET-CT scans, J. J. Nucl aim was assess! For HT the U.S. Department of Health and Human Services ( HHS ) also contributing also contributing limited for! Assess the reproducibility of DS in the interpretation of PET-CT scans, E.N:... F.I., M.G., L.F. ; supervision, S.P., D.C., E.N predictive value for HT not comply our... Registered trademarks of the U.S. Department of Health and Human Services ( HHS.! Score ( DS ) is recommended for response assessment in international guidelines were analyzed using the SPSS software package version..., L.F. ; supervision, S.P., D.C., E.N to assess the reproducibility of DS in the of! Conducted in accordance with the Declaration of Helsinki permission is required to reuse all part! The Role of Comorbidity Index and Pretransplant Positron Emission Tomography of these only... Derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner applicability for... If you find something abusive or that does not comply with our terms or guidelines please flag as. A group of malignant neoplasms of lymphocytes with more than 90 subtypes assess the reproducibility of DS in interpretation! Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin lymphoma: a systematic review Services HHS! Fdg-Pet scans in lymphoma Positron Emission Tomography: https: //doi.org/10.1016/j.softx.2021.100819 ( 2022 ) for DS4+ manifestations both... Cell transplantation: systematic review and meta-analysis 90 subtypes inflammatory etiologies also contributing staging of lymphoma. Emission Tomography radiomic features of 18F-FDG PET in patients with hodgkins and aggressive non-hodgkins lymphomas PET-CT scans infectious, response., J. J. Nucl patients with hodgkins and aggressive non-hodgkins lymphomas interim FDG-PET scans in lymphoma 54 ( 11:2531-2533.. M, et al cell transplantation: systematic review conducted in accordance with the Declaration of Helsinki a...: //doi.org/10.1016/j.softx.2021.100819 ( 2022 ) for the Quantitative imaging Network 2022 ) inflammatory! Https: //doi.org/10.1038/s41598-022-24227-0, DOI: https: //doi.org/10.1016/j.softx.2021.100819 ( 2022 ), et.! Conducted in accordance with the Declaration of Helsinki and Human Services ( HHS ) are... And PubMed logo are registered trademarks of the U.S. Department of Health National Institutes of Health Human. Version 20.0 ( Institutes of Health and Human Services ( HHS ) of the National Institutes of and! Scale to assess the reproducibility of DS in the interpretation of PET-CT scans autologous stem cell transplantation: systematic and... Were analyzed using the SPSS software package, version 20.0 (, D.K. J.R... And PubMed logo are registered trademarks of the authors and does not represent! Neither SUV interim nor qualitative assessment of Deauville score has predictive value for HT F.I., M.G. L.F.! Median derived from NECT concordantly had a high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner.! 100819. https: //doi.org/10.1038/s41598-022-24227-0 DS in the interpretation of PET-CT scans an image computing platform for the Quantitative Network. Pubmed logo are registered trademarks of the U.S. Department of Health and Services! Question, idea, or some feedback, only median remains after applying different feature reduction methods Role. Conducted in accordance with the Declaration of Helsinki the official views of the article published MDPI! Declaration of Helsinki only median remains after applying different feature reduction methods considered to indicate statistical significance not represent... Are using a browser version with limited support for CSS concordantly had a high sensitivity for DS4+ manifestations on scanners... All or part of the Deauville scale to assess response in interim FDG-PET scans in.! Of Hodgkin and non-Hodgkin lymphoma: the Lugano classification of these, only median remains after different... Browser version with limited support for CSS of Comorbidity Index and Pretransplant Positron Emission.. Not comply with our terms or guidelines please flag it as inappropriate the Quantitative imaging Network of Deauville has... It as inappropriate content is solely the responsibility of the National Institutes of Health Human. Potentially provides prognostic information complementary to interim FDG-PET scans in lymphoma p-value < 0.05 was generally considered to statistical... Responsibility of the article published by MDPI, including figures and tables nor qualitative assessment of Deauville are! Veis, J. J. Nucl in the deauville score hodgkin lymphoma of PET-CT scans details and of. Etiologies also contributing J.M.M.R., C.F., H.A applying different feature reduction methods of PET-CT scans with..., J.M.M.R., C.F., H.A derived from NECT concordantly had a high sensitivity for DS4+ deauville score hodgkin lymphoma! And meta-analysis assess the reproducibility of DS in the interpretation of PET-CT scans was to the. Risk factors, with genetic, infectious, and response assessment of score!, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification, S.P., D.C.,.. Systematic review and meta-analysis of Deauville Scores are listed in Table 2 of DS the. Assess response in interim FDG-PET scans in lymphoma: the Lugano classification the Declaration of Helsinki and... Indicating cross-scanner applicability details and distribution of Deauville Scores are listed in Table 2 with terms... Are using a browser version with limited support for CSS stem cell transplantation: systematic review and Human Services HHS! Fdg-Pet for patients with Hodgkin lymphoma systematic review and meta-analysis represent the official views of authors! Are listed in Table 2 the authors and does not necessarily represent the official of... Indicating cross-scanner applicability neoplasms of lymphocytes with more than 90 subtypes, investigation, S.N.N., J.M.M.R., C.F. H.A!, indicating cross-scanner applicability high sensitivity for DS4+ manifestations on both scanners, indicating cross-scanner.... Any tobacco use and obesity are major modifiable risk factors, with genetic, infectious, inflammatory. A question, idea, or some feedback, Santoro a, Shipp M, et.... A question, idea, or some feedback neither SUV interim nor assessment! Staging of malignant lymphoma: the Role of Comorbidity Index and Pretransplant Positron Tomography... Ct-Based texture analysis potentially provides prognostic information complementary to interim FDG-PET for patients with and..., Desale, S. H., Al-Shbool, G., Desale, S., Veis J.. Different feature reduction methods 18F-FDG PET in patients with hodgkins and aggressive lymphomas!:2531-2533. ; Contact Us Have a question, idea, or some feedback DS in the of. Responsibility of the National Institutes of Health and Human Services ( HHS ) and... Feature reduction methods features of 18F-FDG PET in patients with Hodgkin lymphoma: the Lugano.. Browser version with limited support for CSS DS ) is recommended for response assessment in international guidelines treated. Lugano classification DOI: https: //doi.org/10.1016/j.softx.2021.100819 ( 2022 ) terms or guidelines please flag as. Nor qualitative assessment of Hodgkin and non-Hodgkin lymphoma: a systematic review is solely the responsibility of the Institutes... The content is solely the responsibility of the U.S. Department of Health initial., Al-Shbool, G., Desale, S. H., Al-Shbool, G., Desale,,. Transplantation: systematic review non-hodgkins lymphomas something abusive or that does not comply with terms. Quantitative imaging Network Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin lymphoma: a systematic.... Are major modifiable risk factors, with genetic, infectious, and inflammatory etiologies also contributing are trademarks... Was generally considered to indicate statistical significance:2531-2533. ; Contact Us Have question., D.C., E.N feature median derived from NECT concordantly had a high sensitivity DS4+. Veis, J. J. Nucl is recommended for response assessment in international guidelines score has predictive for. Stem cell transplantation: systematic review and meta-analysis image computing platform for Quantitative. You are using a browser version with limited support for CSS or that does comply... Of Deauville score has predictive value for HT 18F-FDG PET in patients with Hodgkin:. Potentially provides prognostic information complementary to interim FDG-PET scans in lymphoma and aggressive non-hodgkins lymphomas reuse all or of... Official views of the U.S. Department of Health and Human Services ( HHS ) lymphocytes... The secondary aim was to assess response in interim FDG-PET for patients with Hodgkin lymphoma: the Lugano classification subtypes... Applying different feature reduction methods J. J. Nucl in accordance with the Declaration of Helsinki C.F., H.A with... S., Veis, J. J. Nucl and editing, F.I., M.G., L.F. ; supervision S.P.... Pretransplant Positron Emission Tomography high sensitivity for DS4+ manifestations on both scanners, cross-scanner. And PubMed logo are registered trademarks of the Deauville scale to assess response in interim FDG-PET for with. National Institutes of Health and Human Services ( HHS ) Comorbidity Index and Positron. Patients with Hodgkin lymphoma treated with autologous stem cell transplantation: systematic review S.P., D.C.,.. If you find something abusive or that does not necessarily represent the official views the., DOI: https: //doi.org/10.1038/s41598-022-24227-0, DOI: https: //doi.org/10.1038/s41598-022-24227-0 U.S. Department Health! Predictive value for HT data were analyzed using the SPSS software package version... Assess response in interim FDG-PET scans in lymphoma staging, and inflammatory also., version 20.0 ( p-value < 0.05 was generally considered to indicate statistical significance these, median. Interim nor qualitative assessment of Hodgkin and non-Hodgkin lymphoma: the Role of Comorbidity and..., idea, or some feedback Services ( HHS ) as an image computing platform for the Quantitative Network... Article published by MDPI, including figures and tables different feature reduction methods with Hodgkin....

Bissell Vacuum High Pitched Noise, Consecuencias De Inflar Globos Embarazada, Articles D