, Chatzidionysiou K MeSH These results enabled its use as a gold standard for assessing flare and defining flare severity in several studies [21, 67, 88]. Merrill JT Gyri N et al. Criterion validity is defined as the degree to which the scores of an instrument adequately reflect the truth in the form of a gold standard [107]. In 89 studies [2, 3, 913, 21102] the PGA was used to measure disease activity as a whole, therefore satisfying the content validity criteria. van Vollenhoven R , Khamashta MA When expanded it provides a list of search options that will switch the search inputs to match the current selection. Castrejn I, Ra-Figueroa I, Rosario MP, Carmona L. Reumatol Clin. The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. , Arora S Data regarding divergent validity are lacking for the PGA. This is a top barrier, both for treat-to-target management of SLE patients in clinical practice, as well as in clinical trials for new SLE treatments. An international panel of 79 SLE experts participated in a three-round Delphi consensus . Impact of anti-SARS-CoV-2 antibodies of different isotypes (IgA, IgG, IgM) on attainment of PGA . Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can occur with or without systemic lupus erythematosus (SLE). et al. Clinical composite measures of disease activity and damage used to evaluate patients with systemic lupus erythematosus: A systematic literature review. et al. , Gomez A Mok CC In our centre, new tools for the assessment of SLE activity: the Lupus Activity Scoring Tool (LAST) and Clinical Lupus Activity Scoring Tool (C-LAST) were developed and validated. The Physician's Global Assessment (PGA) is a pragmatic disease activity measure, using a 100 mm visual analogue scale (VAS) for physicians to quantify the patient's overall disease . RN-BSN HOLISTIC HEALTH ASSESSMENT ACROSS THE LIFESPAN (NURS 3315) Sociology of Social Problems (SOC213) , Mina R Nehring J Construct validity was demonstrated by a good correlation (r 0.50) between the PGA with the SLEDAI (12 studies), SLAM (4 studies), LAI, BILAG and ECLAM (2 studies each). et al. [84] expressed the sensitivity in PGA scoring with the standardized response mean (SRM), demonstrating a very large effect size (ES=2.23) [110]. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. SLE2ACR1997SLICC2012. Medical-Surgical Nursing Clinical Lab (NUR1211L) U.S. History Themes (HIS-144) Nursing Process IV: Medical-Surgical Nursing (NUR 411) Maternity Nursing Care; Professional Roles and Values (C 304) Survey of United States History (C121) Trending. , Lau CS , Hochberg M. Touma Z , Kalunian K In only one study [4], was PGA sensitivity assessed comparing the change with an anchor [109], represented by the treatment sensitive index: PGA sensitivity was found to be between that of the BILAG (highest sensitivity) and the SLEDAI (lowest sensitivity). Definition: At least a 20%, 40%, 50%, or 70% improvement and an absolute improvement of at least 1 unit on a scale of 1-10 in at least three of the following criteria: patient global assessment; pain; function (BASFI); and. HHS Vulnerability Disclosure, Help An international panel of 79 SLE experts participated in a three-round Delphi consensus process, in which 41 statements related to the PGA in SLE were . , Farewell V , Adamichou C , Mikolaitis-Preuss RA , Petri M. Thanou A , Rodrigues M Mok CC AU - Morand, Eric. Despite the need for new treatments in CLE . , Mohan C. Giangreco D , James JA , Gladman DD Rendas-Baum R, Baranwal N, Joshi AV, Park J, Kosinski M. J Patient Rep Outcomes. , Birmingham DJ Reviews and case series with fewer than five patients were excluded. CLOSED ANGLE/ ANGLE CLOSURE GLAUCOMA. . 2014 Sep-Oct;10(5):309-20. doi: 10.1016/j.reuma.2014.01.012. Fanouriakis A The literature search identified 93 articles, and 12 additional articles were retrieved from the reference list of those publications. Epub 2014 Jul 10. The aim of this systematic literature review (SLR) is to describe and analyse the psychometric properties of PGA. , Jnsen A , Koutsoviti S The company serves physicians and patients. The https:// ensures that you are connecting to the Arriens C We have systematically reviewed all studies about validation of the PGA in SLE. Correspondence to: Laurent Arnaud, Service de Rhumatologie, Centre National de Rfrence des Maladies Autoimmunes et Systmiques Rares, Hpital de Hautepierre, 1 Avenue Molire BP 83049, 67098 Strasbourg Cedex, France. PGA; disease activity; physician global assessment; psychometrics; systemic lupus erythematosus. Touma Z Brunner HI , Petri MA Your comment will be reviewed and published at the journal's discretion. The aim of this systematic literature review is to describe and analyse the . , Chakravarty E Fanouriakis A Methods: , Genovese M The PGA was integrated in composite indices, including the definition of the LLDAS [12, 13, 29, 34, 37, 39, 40] and remission [29, 37] (Table1). A high variability in scales was found, causing a wide range of reliability (intraclass correlation coefficient 0.67-0.98). Measurement properties of the PGA were analysed according to the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) terminology [19]. , Glassman DS FOIA They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). It operates in Albuquerque, and New Mexico. et al. 25 (FIVE YEARS 8) Latest Documents Most Cited Documents Contributed Authors Related Sources Related Keywords Latest Documents; Most Cited Documents; Contributed Authors; Related Sources; , Fang H Thanou A Epub 2014 Apr 11. Objective: Convergent validity is fulfilled indirectly in studies where the PGA is used as the gold standard to assess the construct validity of other indices. AU - Kandane-Rathnayake, Rangi. et al. The Systemic Lupus Activity Measure-revised, the Mexican Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. A prospective cohort study, Validity and reliability of retrospective assessment of disease activity and flare in observational cohorts of lupus patients, A novel lupus activity index accounting for glucocorticoids: SLEDAI-2K glucocorticoid index, Low disease activityirrespective of serologic status at baselineassociated with reduction of corticosteroid dose and number of flares in patients with systemic lupus erythematosus treated with belimumab: a real-life observational study, Definition and initial validation of a lupus low disease activity state (LLDAS), A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS), Prolonged remission in Caucasian patients with SLE: prevalence and outcomes, 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus, PRISMA Group. , Friebus-Kardash J All articles published through 1 July 2019 in PubMed were screened, with no limitation on year of publication, language or patients age. Pincus and colleagues conducted a study of . BILAGAB . In the last 30years, more than a dozen scores have been derived to assess disease activity in SLE, but not all of these have proven to be valid and reliable tools. Responsiveness, or sensitivity to change, is the usefulness of a test to detect minimum clinically important differences [20, 109]. Oxford University Press is a department of the University of Oxford. , Suriano A The site is secure. et al. , Wallace DJ , Perneger T Patient global assessment (PGA) is one of the most widely used PROs in RA practice and research and is included in several composite scores such as the 28-joint Disease Activity Score (DAS28). Genetic linkage has related dysfunction of . An acceptable reliability is indicated by values of intraclass correlation coefficient (ICC) or weighted >0.60 and a good reliability is >0.85 [20]. The LUMINA (Lupus in Minorities: Nature versus Nurture) study and other trials have offered evidence of a decrease in flares and prolonged life in patients given hydroxychloroquine, making . , Matos A Discrimination refers to whether the score (PGA-VAS) differentiates between situations of interest [18]: discrimination of the PGA measures the ability of the PGA-VAS to report a consistent score where no change in disease activity has occurred (reliability) and to detect a change when a change in disease activity has occurred (sensitivity to change or responsiveness). , Kosinski M Presence of at least one of the following items of serological evidence of active SLE or biological variables predictive of Type 1 Interferon (IFN-1) high signature (in a Screening sample as measured by central laboratory): COSMIN Terminology from a European Rheumatology Perspective: a Glossary for the EULAR PRO Tool Box Initiative. Subsequently the PGA was incorporated in the Safety of Estrogen in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) in 1999 [10], in the Systemic Responder Index (SRI) in 2009 [3, 11, 12] as well as in the definitions of the Lupus Low Disease Activity State (LLDAS) [13] and various definitions of remission [14, 15]. In one open-label study [43], the decrease in PGA score was considered the primary endpoint. , Alunno A , Garabajiu M Criterion validity was assessed exploring the PGA correlation with quality of life measurements, biomarker levels and treatment changes in 28 studies, while no study has evaluated correlation with damage. , Criscione-Schreiber LG The sensitivity to change was estimated to be the smallest for the SLEDAI; the standardized response means were 0.48 when the physician global assessment was used as the standard and 0.01 when the patient global assessment was used . CareerBuilder TIP. The term Physician Global Assessment (PGA) was coined in 1991 by Petri et al. et al. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. [9] for a disease activity index scored on a VAS ranging from 0 to 3, with an increase of 1.0 since the last visit indicating a flare. , Kalunian K Methods: This systematic literature review was conducted by two independent reviewers in accordance with the Preferred Reporting Items .

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